Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.
Identifieur interne : 000A72 ( Main/Exploration ); précédent : 000A71; suivant : 000A73Host Transcription Profile In Nasal Epithelium And Whole Blood of Hospitalised Children under two years of age with Respiratory Syncytial Virus Infection.
Auteurs : Lien Anh Ha Do [Viêt Nam] ; Johann Pellet ; H Rogier Van Doorn [Viêt Nam] ; Anh Tuan Tran [Viêt Nam] ; Bach Hue Nguyen [Viêt Nam] ; Thi Thu Loan Tran [Viêt Nam] ; Quynh Huong Tran [Viêt Nam] ; Quoc Bao Vo [Viêt Nam] ; Nguyen Anh Tran Dac [Viêt Nam] ; Hong Nhien Trinh [Viêt Nam] ; Thi Thanh Hai Nguyen [Viêt Nam] ; Bao Tinh Le Binh [Viêt Nam] ; Huu Mai Khanh Nguyen [Viêt Nam] ; Minh Tien Nguyen [Viêt Nam] ; Quang Tung Thai [Viêt Nam] ; Thanh Vu Vo [Viêt Nam] ; Ngoc Quang Minh Ngo [Viêt Nam] ; Thi Kim Huyen Dang [Viêt Nam] ; Ngoc Huong Cao [Viêt Nam] ; Thu Van Tran [Viêt Nam] ; Lu Viet Ho [Viêt Nam] ; Bertrand De Meulder ; Charles Auffray ; Jorrit-Jan Hofstra [Pays-Bas] ; Jeremy Farrar [Viêt Nam] ; Juliet E. Bryant [Viêt Nam] ; Menno De Jong [Viêt Nam] ; Martin L. HibberdSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2017.
Abstract
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon alpha/beta, NOTCH1 signaling pathways and potential biomarkers HIST1H4E, IL7R, ISG15 in NP samples, or BCL6, HIST2H2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and severity. The observed RSV-induced gene expression patterns did not differ significantly in NP and blood specimens. In contrast, hRV infection did not as strongly induce expression of innate immunity pathways, and significant differences were observed between NP and blood specimens. We conclude that RSV induced strong and persistent innate immune responses and that RSV severity may be related to development of T follicular helper cells and antiviral inflammatory sequelae derived from high activation of BCL6.
DOI: 10.1093/infdis/jix519
PubMed: 29029245
Affiliations:
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Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Vo, Thanh Vu" sort="Vo, Thanh Vu" uniqKey="Vo T" first="Thanh Vu" last="Vo">Thanh Vu Vo</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Ngo, Ngoc Quang Minh" sort="Ngo, Ngoc Quang Minh" uniqKey="Ngo N" first="Ngoc Quang Minh" last="Ngo">Ngoc Quang Minh Ngo</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Dang, Thi Kim Huyen" sort="Dang, Thi Kim Huyen" uniqKey="Dang T" first="Thi Kim Huyen" last="Dang">Thi Kim Huyen Dang</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Ngoc Huong" sort="Cao, Ngoc Huong" uniqKey="Cao N" first="Ngoc Huong" last="Cao">Ngoc Huong Cao</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Thu Van" sort="Tran, Thu Van" uniqKey="Tran T" first="Thu Van" last="Tran">Thu Van Tran</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Lu Viet" sort="Ho, Lu Viet" uniqKey="Ho L" first="Lu Viet" last="Ho">Lu Viet Ho</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="De Meulder, Bertrand" sort="De Meulder, Bertrand" uniqKey="De Meulder B" first="Bertrand" last="De Meulder">Bertrand De Meulder</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation><wicri:noCountry code="subField">69007 Lyon - France</wicri:noCountry></affiliation></author><author><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation><wicri:noCountry code="subField">69007 Lyon - France</wicri:noCountry></affiliation></author><author><name sortKey="Hofstra, Jorrit Jan" sort="Hofstra, Jorrit Jan" uniqKey="Hofstra J" first="Jorrit-Jan" last="Hofstra">Jorrit-Jan Hofstra</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Bryant, Juliet E" sort="Bryant, Juliet E" uniqKey="Bryant J" first="Juliet E" last="Bryant">Juliet E. Bryant</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="De Jong, Menno" sort="De Jong, Menno" uniqKey="De Jong M" first="Menno" last="De Jong">Menno De Jong</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name><affiliation><nlm:affiliation>Genome Institute of Singapore, #02-01, Genome Building, 60 Biopolis Street, Singapore 138672.</nlm:affiliation><wicri:noCountry code="subField">Singapore 138672</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29029245</idno><idno type="pmid">29029245</idno><idno type="doi">10.1093/infdis/jix519</idno><idno type="wicri:Area/PubMed/Corpus">000567</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000567</idno><idno type="wicri:Area/PubMed/Curation">000565</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000565</idno><idno type="wicri:Area/PubMed/Checkpoint">000565</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000565</idno><idno type="wicri:Area/Ncbi/Merge">005032</idno><idno 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Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Pellet, Johann" sort="Pellet, Johann" uniqKey="Pellet J" first="Johann" last="Pellet">Johann Pellet</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation><wicri:noCountry code="subField">69007 Lyon - France</wicri:noCountry></affiliation></author><author><name sortKey="Van Doorn, H Rogier" sort="Van Doorn, H Rogier" uniqKey="Van Doorn H" first="H Rogier" last="Van Doorn">H Rogier Van Doorn</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Anh Tuan" sort="Tran, Anh Tuan" uniqKey="Tran A" first="Anh Tuan" last="Tran">Anh Tuan Tran</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Bach Hue" sort="Nguyen, Bach Hue" uniqKey="Nguyen B" first="Bach Hue" last="Nguyen">Bach Hue Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Thi Thu Loan" sort="Tran, Thi Thu Loan" uniqKey="Tran T" first="Thi Thu Loan" last="Tran">Thi Thu Loan Tran</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Quynh Huong" sort="Tran, Quynh Huong" uniqKey="Tran Q" first="Quynh Huong" last="Tran">Quynh Huong Tran</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Vo, Quoc Bao" sort="Vo, Quoc Bao" uniqKey="Vo Q" first="Quoc Bao" last="Vo">Quoc Bao Vo</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Tran Dac, Nguyen Anh" sort="Tran Dac, Nguyen Anh" uniqKey="Tran Dac N" first="Nguyen Anh" last="Tran Dac">Nguyen Anh Tran Dac</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Trinh, Hong Nhien" sort="Trinh, Hong Nhien" uniqKey="Trinh H" first="Hong Nhien" last="Trinh">Hong Nhien Trinh</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Thi Thanh Hai" sort="Nguyen, Thi Thanh Hai" uniqKey="Nguyen T" first="Thi Thanh Hai" last="Nguyen">Thi Thanh Hai Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Le Binh, Bao Tinh" sort="Le Binh, Bao Tinh" uniqKey="Le Binh B" first="Bao Tinh" last="Le Binh">Bao Tinh Le Binh</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Huu Mai Khanh" sort="Nguyen, Huu Mai Khanh" uniqKey="Nguyen H" first="Huu Mai Khanh" last="Nguyen">Huu Mai Khanh Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Minh Tien" sort="Nguyen, Minh Tien" uniqKey="Nguyen M" first="Minh Tien" last="Nguyen">Minh Tien Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Thai, Quang Tung" sort="Thai, Quang Tung" uniqKey="Thai Q" first="Quang Tung" last="Thai">Quang Tung Thai</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Vo, Thanh Vu" sort="Vo, Thanh Vu" uniqKey="Vo T" first="Thanh Vu" last="Vo">Thanh Vu Vo</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Ngo, Ngoc Quang Minh" sort="Ngo, Ngoc Quang Minh" uniqKey="Ngo N" first="Ngoc Quang Minh" last="Ngo">Ngoc Quang Minh Ngo</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 1, 341 Su Van Hanh, Ward 10, District 10, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Dang, Thi Kim Huyen" sort="Dang, Thi Kim Huyen" uniqKey="Dang T" first="Thi Kim Huyen" last="Dang">Thi Kim Huyen Dang</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Cao, Ngoc Huong" sort="Cao, Ngoc Huong" uniqKey="Cao N" first="Ngoc Huong" last="Cao">Ngoc Huong Cao</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Tran, Thu Van" sort="Tran, Thu Van" uniqKey="Tran T" first="Thu Van" last="Tran">Thu Van Tran</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Lu Viet" sort="Ho, Lu Viet" uniqKey="Ho L" first="Lu Viet" last="Ho">Lu Viet Ho</name><affiliation wicri:level="1"><nlm:affiliation>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Children Hospital 2, 14 Ly Tu Trong, Ben Nghe Ward, District 1, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="De Meulder, Bertrand" sort="De Meulder, Bertrand" uniqKey="De Meulder B" first="Bertrand" last="De Meulder">Bertrand De Meulder</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation><wicri:noCountry code="subField">69007 Lyon - France</wicri:noCountry></affiliation></author><author><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><affiliation><nlm:affiliation>European Institute for Systems Biology and Medicine, 50 avenue Tony Garnier, 69007 Lyon - France.</nlm:affiliation><wicri:noCountry code="subField">69007 Lyon - France</wicri:noCountry></affiliation></author><author><name sortKey="Hofstra, Jorrit Jan" sort="Hofstra, Jorrit Jan" uniqKey="Hofstra J" first="Jorrit-Jan" last="Hofstra">Jorrit-Jan Hofstra</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Bryant, Juliet E" sort="Bryant, Juliet E" uniqKey="Bryant J" first="Juliet E" last="Bryant">Juliet E. Bryant</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="De Jong, Menno" sort="De Jong, Menno" uniqKey="De Jong M" first="Menno" last="De Jong">Menno De Jong</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Program, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author><author><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name><affiliation><nlm:affiliation>Genome Institute of Singapore, #02-01, Genome Building, 60 Biopolis Street, Singapore 138672.</nlm:affiliation><wicri:noCountry code="subField">Singapore 138672</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments. Interferon alpha/beta, NOTCH1 signaling pathways and potential biomarkers HIST1H4E, IL7R, ISG15 in NP samples, or BCL6, HIST2H2AC, CCNA1 in blood are leading pathways and hub genes that were associated with both RSV load and severity. The observed RSV-induced gene expression patterns did not differ significantly in NP and blood specimens. In contrast, hRV infection did not as strongly induce expression of innate immunity pathways, and significant differences were observed between NP and blood specimens. We conclude that RSV induced strong and persistent innate immune responses and that RSV severity may be related to development of T follicular helper cells and antiviral inflammatory sequelae derived from high activation of BCL6.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Viêt Nam</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><noCountry><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><name sortKey="De Meulder, Bertrand" sort="De Meulder, Bertrand" uniqKey="De Meulder B" first="Bertrand" last="De Meulder">Bertrand De Meulder</name><name sortKey="Hibberd, Martin L" sort="Hibberd, Martin L" uniqKey="Hibberd M" first="Martin L" last="Hibberd">Martin L. Hibberd</name><name sortKey="Pellet, Johann" sort="Pellet, Johann" uniqKey="Pellet J" first="Johann" last="Pellet">Johann Pellet</name></noCountry><country name="Viêt Nam"><noRegion><name sortKey="Do, Lien Anh Ha" sort="Do, Lien Anh Ha" uniqKey="Do L" first="Lien Anh Ha" last="Do">Lien Anh Ha Do</name></noRegion><name sortKey="Bryant, Juliet E" sort="Bryant, Juliet E" uniqKey="Bryant J" first="Juliet E" last="Bryant">Juliet E. Bryant</name><name sortKey="Cao, Ngoc Huong" sort="Cao, Ngoc Huong" uniqKey="Cao N" first="Ngoc Huong" last="Cao">Ngoc Huong Cao</name><name sortKey="Dang, Thi Kim Huyen" sort="Dang, Thi Kim Huyen" uniqKey="Dang T" first="Thi Kim Huyen" last="Dang">Thi Kim Huyen Dang</name><name sortKey="De Jong, Menno" sort="De Jong, Menno" uniqKey="De Jong M" first="Menno" last="De Jong">Menno De Jong</name><name sortKey="Farrar, Jeremy" sort="Farrar, Jeremy" uniqKey="Farrar J" first="Jeremy" last="Farrar">Jeremy Farrar</name><name sortKey="Ho, Lu Viet" sort="Ho, Lu Viet" uniqKey="Ho L" first="Lu Viet" last="Ho">Lu Viet Ho</name><name sortKey="Le Binh, Bao Tinh" sort="Le Binh, Bao Tinh" uniqKey="Le Binh B" first="Bao Tinh" last="Le Binh">Bao Tinh Le Binh</name><name sortKey="Ngo, Ngoc Quang Minh" sort="Ngo, Ngoc Quang Minh" uniqKey="Ngo N" first="Ngoc Quang Minh" last="Ngo">Ngoc Quang Minh Ngo</name><name sortKey="Nguyen, Bach Hue" sort="Nguyen, Bach Hue" uniqKey="Nguyen B" first="Bach Hue" last="Nguyen">Bach Hue Nguyen</name><name sortKey="Nguyen, Huu Mai Khanh" sort="Nguyen, Huu Mai Khanh" uniqKey="Nguyen H" first="Huu Mai Khanh" last="Nguyen">Huu Mai Khanh Nguyen</name><name sortKey="Nguyen, Minh Tien" sort="Nguyen, Minh Tien" uniqKey="Nguyen M" first="Minh Tien" last="Nguyen">Minh Tien Nguyen</name><name sortKey="Nguyen, Thi Thanh Hai" sort="Nguyen, Thi Thanh Hai" uniqKey="Nguyen T" first="Thi Thanh Hai" last="Nguyen">Thi Thanh Hai Nguyen</name><name sortKey="Thai, Quang Tung" sort="Thai, Quang Tung" uniqKey="Thai Q" first="Quang Tung" last="Thai">Quang Tung Thai</name><name sortKey="Tran Dac, Nguyen Anh" sort="Tran Dac, Nguyen Anh" uniqKey="Tran Dac N" first="Nguyen Anh" last="Tran Dac">Nguyen Anh Tran Dac</name><name sortKey="Tran, Anh Tuan" sort="Tran, Anh Tuan" uniqKey="Tran A" first="Anh Tuan" last="Tran">Anh Tuan Tran</name><name sortKey="Tran, Quynh Huong" sort="Tran, Quynh Huong" uniqKey="Tran Q" first="Quynh Huong" last="Tran">Quynh Huong Tran</name><name sortKey="Tran, Thi Thu Loan" sort="Tran, Thi Thu Loan" uniqKey="Tran T" first="Thi Thu Loan" last="Tran">Thi Thu Loan Tran</name><name sortKey="Tran, Thu Van" sort="Tran, Thu Van" uniqKey="Tran T" first="Thu Van" last="Tran">Thu Van Tran</name><name sortKey="Trinh, Hong Nhien" sort="Trinh, Hong Nhien" uniqKey="Trinh H" first="Hong Nhien" last="Trinh">Hong Nhien Trinh</name><name sortKey="Van Doorn, H Rogier" sort="Van Doorn, H Rogier" uniqKey="Van Doorn H" first="H Rogier" last="Van Doorn">H Rogier Van Doorn</name><name sortKey="Vo, Quoc Bao" sort="Vo, Quoc Bao" uniqKey="Vo Q" first="Quoc Bao" last="Vo">Quoc Bao Vo</name><name sortKey="Vo, Thanh Vu" sort="Vo, Thanh Vu" uniqKey="Vo T" first="Thanh Vu" last="Vo">Thanh Vu Vo</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Hofstra, Jorrit Jan" sort="Hofstra, Jorrit Jan" uniqKey="Hofstra J" first="Jorrit-Jan" last="Hofstra">Jorrit-Jan Hofstra</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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